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N.A. Pakharukova L.Kh. Pastushkova I.M. Larina A.I. Grigoriev 《Acta Astronautica》2011,68(9-10):1523-1528
The aim of this study was to characterize changes of serum proteome profile during 7-day “dry” immersion (DI). The experiment with DI consisted of three series: control group without countermeasures (10 men), with using mechanical stimulation (6 men) and low-frequency myostimulation (5 men) as preventive means. Serum samples were fractionated using ClinProt robot (Bruker Daltonics) on magnetic beads (weak cation exchange magnetic beads—MB WCX) prior to mass-spectral profiling. It was obtained 170 peaks after fractionation of serum samples in each group. On 7th immersion day peak areas of fibrinopeptide A (m/z=1206; 1464), angiotensin II (m/z=1051), high molecular mass kininogen fragment (m/z=2133 Da) and C3-fragment of the complement system (m/z=1350 Da) were significantly decreased comparing with pre-experimental values of all experimental series. Peak areas of apolipoprotein C III (m/z=9419) and C4a fragment of the complement system (m/z=3206 Da) were increased. On 7th day of the recovery peak areas of all changed peaks were not close to pre-experimental values. This fact provided evidence of incomplete recovery of an organism after DI. The depth of the alterations had considerable individual variability. Thereby the detected changes of serum proteome profile in the experiment. They indicated a reorganization of the hormonal, immune systems and lipid metabolism. The use of myostimulation and mechanical stimulation as countermeasures partly compensated adverse effects of 7-day dry immersion on the parameters of coagulation system (fibrinopeptide A) and lipid metabolism (apolipoprotein CIII). 相似文献
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针对柔性航天器姿态机动的“快速性”及“稳定性”矛盾,研究了一种优化与控制综合的姿态机动轨迹设计与跟踪控制方法。首先,考虑柔性航天器姿态机动过程中既快又稳的需求,建立姿态机动的多目标多约束条件,优化获得姿态机动轨迹,在满足快速性基础上,最大限度提高稳定性;其次,设计新型的快速鲁棒输入成形器(FRIS),与传统输入成形器相比,FRIS具有更短的作用时间及更强的鲁棒性,能够有效抑制柔性附件振动,为姿态机动的“快速性”及“高精度”奠定基础;最后,设计新型自适应连续终端滑模控制器(ACTSMC),避免增益过估计,提高控制精度,实现对期望姿态轨迹的有限时间快速高精度跟踪控制。数值仿真校验了所提方法的有效性。 相似文献
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多相电机在定子开路故障下具有良好的容错性能,与此相关的设备和控制策略改进方面的研究理论也不断被提出。然而,却少有基于统一模型的适用于多相开路故障的容错控制策略。提出了一种应用于双三相永磁同步电机(PMSM)系统三相或三相以下开路故障的容错控制策略,并获得了良好的电机电力和动态性能。针对发生单相到三相开路故障的PMSM提出了统一数学模型,提取出每种故障下对应电机不对称性的矩阵。通过电压方程,推导出每种故障对应的解耦变换矩阵。为了对相电流中的每种谐波进行无差别抑制,建立了谐波子空间。考虑开路故障相数的增加,提出了用于三相开路的有中性点电流的容错控制策略,达到了降低相电流幅值和提升系统冗余度的目的。最后通过试验和仿真结果,验证了理论分析的正确性。 相似文献
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